Has Protein Folding Been Solved?

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Refreshing to hear someone use “exponentially” when it actually applies.

Sabine - really appreciate you taking the time to explain these complex topics to us. Thank you!

A few clarifications: CryoEM doesn't generally give better resolution (it was actually worse than crystallography until recently), but it also works on many proteins that are not amenable to crystallization (e.g. membrane proteins). That's why it's so useful. Also, oligomers are not several amino acids interacting, but several distinct amino acid chains (i.e. proteins).

The silver rule of broadcasting: Whenever there is a question in a headline, the answer is always NO.

My headphone cord thinks it's a protein...very annoying.

As a biochemist who worked both with x-ray crystallography and cryo-EM, a few comments: a) this is an excellent video, but i also never expected anything other than awesome from Sabine b) even if alpha fold performs less well for complexes or unusual folds, still it would be great if it could releive the burden of having to determine the structures of hundreds upon hundreds of similar proteins. This would free up valuable people and equipment to concentrate on the very unusual and complicated structures c) even if it doesn't revolutionize basic biochemistry, it can be of tremendous help to pharmaceutical research as they often work on relatively common folds (e.g. spike protein of Covid when you already know the spike structures of several other coronaviruses)

Hi Sabine, I'm echoing what a lot of other folks have already stated. I really enjoy the diversity of topics that you present, and your well thought out presentation too. Thank you.

Excellent. I learned so much in 12 minutes about a subject I was totally ignorant of.

This was just an absolutely fascinating topic. I had heard of this problem years ago, but never bothered looking into it. Sabine's ability to unravel the complexity of such issues is remarkable.

I just started my PhD in peptide folding and chemistry and then comes this news!! 😅

Sabine's social work in disseminating knowledge on such a wide range of scientific topics is invaluable.

Thank you for clarifying this difficult information for lay people like me. Yours is a vital service and you are so good at it. Getting the general public to 'somewhat' understand the amazing discoveries coming so fast now is urgent.

You deserve a lot of respect for exposing us to different domains and questions in science. In a very understandable way too.

"That's almost as many vacua as there are in String Theory" -- priceless 🤣

Congratulations on 200k, much deserved

CASP updated the scoring algorithm in 2014 and the top scores have increased linearly since then. The C-alpha “IDDT” distance scoring is based only on C-alpha positions - that is one atom out of all other amino acid atomic positions. There are other scoring calculations too.

''some of you may have folded proteins yourself'' YES I HAVE WeLL IM ALIVE, that's why!~😂🤣

Great explanation and nice seeing more Biology content on here, as a Biologist myself!

You are one of the best and honest youtuber. No hype, to the point explanations.