Dr. Gary Steinberg: How to Improve Brain Health & Offset Neurodegeneration

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Published 2024-05-20
In this episode, my guest is Dr. Gary Steinberg, MD, PhD, a neurosurgeon and a professor of neurosciences, neurosurgery, and neurology at Stanford University School of Medicine. We discuss brain health and brain injuries, including concussion, traumatic brain injury (TBI), stroke, aneurysm, and transient ischemic attacks (TIA). We discuss key and lesser-known risk factors for brain health and explain how certain treatments and medications can improve brain health and cognitive function.

We also cover novel mechanisms to improve recovery after concussions and brain injury, including the use of stem cells, temperature (mild hypothermia), and vagus nerve stimulation. Dr. Steinberg also describes new advances in neurosurgery and minimally invasive brain augmentation.

This episode ought to be of interest to anyone seeking actionable tools to improve their brain health and for those seeking to improve recovery after a brain injury such as concussion, stroke, aneurysm, or TBI.

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Dr. Gary Steinberg
Stanford academic profile: stan.md/3WLmBV2
Stanford Health Care clinical profile: shc.is/4dProuA
Lab website: stan.md/4dKFnlA
"Why I Went into Medicine: Gary Steinberg, MD, PhD" (video story):    • Why I Went into Medicine: Gary Steinb...  
Publications: stan.md/3WMNCaw

Articles
The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy: go.nature.com/3UP80oZ
Transplanted Stem Cell-Secreted Vascular Endothelial Growth Factor Effects Poststroke Recovery, Inflammation, and Vascular Repair: bit.ly/3UFNRSg
Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain: bit.ly/3UQFByY
Revisiting Stem Cell-Based Clinical Trials for Ischemic Stroke: bit.ly/4bH4jZk
Two-year safety and clinical outcomes in chronic ischemic stroke patients after implantation of modified bone marrow–derived mesenchymal stem cells (SB623): a phase 1/2a study: bit.ly/4bHLNzT
Mild Hypothermia Reduces Apoptosis of Mouse Neurons In vitro Early in the Cascade: bit.ly/4bH4pjE
Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest: bit.ly/3UNY0wb
Childhood Outcomes after Hypothermia for Neonatal Encephalopathy: bit.ly/3UPvvy5
Slow rewarming improved the neurological outcomes of prolonged mild therapeutic hypothermia in patients with severe traumatic brain injury and an evacuated hematoma: go.nature.com/3UQhiRy
Vision Loss after Intravitreal Injection of Autologous “Stem Cells” for AMD: bit.ly/3UFO5c4

Huberman Lab Episodes Mentioned
Dr. Craig Heller: Using Temperature for Performance, Brain & Body Health:    • Dr. Craig Heller: Using Temperature f...  

People Mentioned
Timothy Schallert: professor of psychology, University of Texas at Austin
Theresa Jones: professor of psychology, University of Texas at Austin
Norma Shumway: father of heart transplantation, Stanford University
Henry Kaplan: discovered radiation exposure to treat leukemia, Stanford University

Timestamps
00:00:00 Dr. Gary Steinberg
00:01:44 Sponsors: Eight Sleep, ROKA & AeroPress; Subscribe on YouTube, Spotify & Apple
00:06:16 Stroke, Hemorrhage & Blood Clot
00:10:25 Blood Clots & Risk Factors, Medications, Smoking, Cholesterol
00:16:19 Heart & Brain Health; Neurosurgery & Brain Function
00:23:27 Current Technology & Neurosurgery, Minimally Invasive Techniques
00:28:13 Transient Ischemic Attacks (TIA); Spinal Cord Strokes
00:33:23 Stroke Risk: Alcohol, Cocaine & Other Drugs
00:38:24 Sponsor: AG1
00:39:55 Traumatic Brain Injury (TBI), Concussion: Sports, Testing & Recovery
00:46:45 Statins; TBI & Aspirin; Caffeine & Stroke Risk
00:48:31 Exploratory MRI: Benefits & Risks
00:51:53 Blood Pressure, Lifestyle Factors; Tool: Feeling Faint, Hydration; Sleep
00:59:52 Sponsor: LMNT
01:01:27 Chiropractic Neck Adjustment & Arterial Obstruction; Inversion Tables
01:05:16 Kids, Tackle Football, Soccer, Boxing; Mild Concussion
01:10:49 Nerve Regeneration, Stem Cells, Stroke Recovery
01:17:36 Stem Cells, Immune System, Activity
01:21:27 Injury & Recovery, Restraint Therapy
01:23:46 Neuroprotection After Injury; Mild Hypothermia
01:34:59 Platelet-Rich Plasma (PRP), Stem Cell Therapy
01:42:27 Scientific Advancements & Clinical Translation, FDA & Industry
01:47:40 Vagal Stimulation
01:53:17 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Social Media, Neural Network Newsletter

#HubermanLab #BrainHealth

Disclaimer: www.hubermanlab.com/disclaimer

All Comments (21)
  • @hubermanlab
    Thank you for watching. If you enjoyed this topic and episode, please click the "like" button and subscribe to our channel here on YouTube. Thank you for your interest in science!
  • In 2002 at the age of 17 I had a grand mal seizure. My mom called Dr. Steinberg’s office crying after getting 2 different opinions. Even though his schedule was full, he found a way to get me in his schedule. He diagnosed me with an arterial venous malformation that caused a vein to leak blood in my brain. He performed surgery on me in October of 2002 and today I’m fully healthy . Dr. Steinberg, I wanted to let you know that I’m now 38, I have had a life filled of love, great relationships and memories because of your work. I was lifting weights before work when I saw your podcast with Dr. Huberman on my YouTube feed, it gave me chills. With love, admiration, and respect, I thank you with all my heart and brain for saving my quality of life. Christ be with you my friend. Dave Purpura
  • I’m so happy to see that you have Dr Steinberg he is my neurosurgeon that looks over me. I have Moyamoya. He saved my life! He is the best.😊
  • Three weeks ago my 14 yr old daughter had an aneurysm burst inside of an AVMin her left frontal lobe. Over the course of 4 days, she had 4 brain surgeries to save her life. One week after the first surgery, she was sent home to recover. Her recovery has been miraculous - in the words of her own doctor. She's still got a ways to go to get her speech and language back but she's doing great and her attitude is that of a warrior (with a smile). She had half a head of hair when she left the hospital and decided to go full buzz cut. We donated 14 inches of her gorgeous hair to a local charity that makes FREE wigs for patients with medical hair loss. When all of this began, you were the first person I wanted to call to see if you knew anything about this... and then you release this (thank you). Reading the comments below of people who have survived similar situations is helping me to get through this. She hardly remembers any of the past few weeks while every second of it is a vivid memory for me. I'll be going back to your PTSD episodes to figure out the help I need to get through this as her mom. Thank you, and Dr. Steinberg, for this episode and for all of the comments below. I'm beyond thankful to the medical team here on Long Island at Cohen's Children's Medical Center and LIJ (Dr. Mark Mittler and Dr. Henry Woo and Dr. Thomas Link) who saved my child.
  • I’m a chiropractor and agree with what the professors are saying be careful with getting your neck aggressively adjusted just ask your chiropractor to not do any twisting cracking adjustments and stick to soft tissue work please and thankyou!
  • @Iamthenextone
    Phenomenal episode, you have to bring him back on. really interesting to understand mild hypothermia procedure and protocol, never knew that.
  • @klakola3662
    Wow Andrew, you literally saved a loved ones Dad from being taken off life support with knowledge from your science community. I love the epic work you are doing.
  • @JenniferMyers
    The episodes on brain health are my favorite! So much has yet to be revealed about the brain; its study provides endless fascination. On a related note, I had a neuron working for me once. I fired him.
  • @mirah2578
    I’m a speech therapist in the medical setting. This episode is very relevant to most of my patients. Thank you
  • Would love to see more on TBI, particularly longer term issues, from brain fog/nausea/exercise intolerance up to CTE
  • @Patricia_CSR
    Please have Bessel Van Der Kolk, the author of “The Body Keeps The Score” on your podcast. I would greatly appreciate it.
  • @lyndaconrad4549
    I was part of the SB623 clinical trial and had some recovery.
  • @nda4591
    Guest Suggestion: 1- John Joseph Hopfield( other than his great scientific contributions, the routine he follows that keeps him mentally sharp in his 90s), 2- Michael Levin Thanks for the great podcast!
  • @caseyvance2791
    Thank you so much for providing this public service, it's literally changed my life and I recommend it to everyone I know. Would you ever consider making an episode on weening off SSRI's/SNRI's/other psych meds? It's rough.
  • @janeca10
    My mother had an aneurism at age 80 , me and my brother took her quick to Quinta Dor Hospital, in Rio. When Doctors told us she was going through an embolization ( via catheter from the groin to get to the brain) , we did not know how safe that was.. and gosh we were afraid! The neurosurgeons saved her life and the best is that she has no sequels from the aneurism embolization.. So we are living in a new world of possibilities. 😍
  • @EcomCarl
    Dr. Steinberg's insights into brain health are enlightening, emphasizing the critical role of lifestyle choices in neurological wellness. Regular check-ups and proactive health management can significantly enhance brain function and prevent degeneration 🧠.
  • @JoeRoganB
    I bet there’s someone who sits down after a long day of work and just stares at huberman’s videos at normal speed. No food, no other entertainment.