The “heroic dose” of psychedelics, according to Johns Hopkins | Dr. Matthew Johnson

7,524,818
0
Published 2022-12-21
How a ‘heroic dose’ of psychedelics can be therapeutic, explained by a Johns Hopkins professor.

Subscribe to Big Think on YouTube ►    / @bigthink  
Up next, Psychedelics: The scientific renaissance of mind-altering drugs
   • Psychedelics: The scientific renaissa...  

Psychedelic research is enjoying a renaissance. Recent studies have shown that psychedelic drugs like LSD and psilocybin seem to be a safe and effective method for treating conditions like depression, anxiety, and post-traumatic stress disorder.

And unlike common antidepressants, some people report long-lasting improvements in their mental health conditions after taking just one dose of psychedelics.

What makes these substances so unique and powerful? That’s one of the driving questions behind the research of Matthew W. Johnson, who has conducted numerous studies on the nature of addiction, psychedelics, and other psychoactive substances.

Read the video transcript ► bigthink.com/series/the-big-think-interview/psyche…

0:00 Effing up the ineffable
1:56 Pioneers of psychedelic therapy
2:35 Psychedelics go underground
3:26 The psychedelic renaissance
4:50 Taking a ‘heroic dose’ at Johns Hopkins
8:44 The challenges of psychedelic therapy
9:46 The mental health revolution
----------------------------------------------------------------------------------

About Matthew Johnson:
Matthew W. Johnson, Ph.D., is The Susan Hill Ward Endowed Professor of Psychedelics and Consciousness Research at Johns Hopkins. Working with psychedelics since 2004, he is one of the world’s most widely published experts on psychedelics. He has published research on psychedelics and mystical experience, personality change, tobacco smoking cessation, cancer distress treatment, and depression treatment. In 2021 he received as principal investigator the first grant in 50 years from the US government for a treatment study with a classic psychedelic, specifically psilocybin in treatment of tobacco addiction. He is also known for his expertise in behavioral economics, addiction, sexual risk behavior, and research with a wide variety of drug classes. He’s been Interviewed by Anderson Cooper on 60 Minutes, the New York Times, the Washington Post, the Wall Street Journal, CNN, NPR, Fox News, Fox Business News, BBC and in Michael Pollan’s book How to Change Your Mind.

----------------------------------------------------------------------------------

Read more of our stories on psychedelics:
AI maps psychedelic “trip” experiences to regions of the brain – opening new route to psychiatric treatments
bigthink.com/health/ai-maps-psychedelic-trip-in-br…
Psychedelic drugs: how to tell good research from bad
bigthink.com/health/psychedelic-drugs-research/
Metaphysics and mushrooms: Psychedelics can change how you think about the universe
bigthink.com/neuropsych/psychedelics-mushrooms-met…

----------------------------------------------------------------------------------

About Big Think | Smarter Faster™
► Big Think
The leading source of expert-driven, educational content. With thousands of videos, featuring experts ranging from Bill Clinton to Bill Nye, Big Think helps you get smarter, faster by exploring the big ideas and core skills that define knowledge in the 21st century.
► Big Think+
Make your business smarter, faster: bigthink.com/plus/

----------------------------------------------------------------------------------

Want more Big Think?
► Daily editorial features: bigthink.com/popular/
► Get the best of Big Think right to your inbox: bigthink.com/st/newsletter
► Facebook: bigth.ink/facebook
► Instagram: bigth.ink/Instagram
► Twitter: bigth.ink/twitter

All Comments (21)
  • @shadw4701
    The fact that psychedelics are still illegal is a crime against humanity
  • Alcohol and cigarettes addiction actually destroyed my life. I could remember several years ago after divorce with my wife which brought me into my disastrous journey on Alcohol and cigarettes. I suffered severe depression and mental disorder. Got diagnosed with cptsd. Not until a friend recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 8 years totally clean. Much respect to mother nature the great magic shrooms.
  • Psychedelic is the answer to most severe anxiety and depression. The use of magic mushrooms completely helps one get over depression and makes you feel like yourself.
  • Psilocybin flipped the off switch on my social anxiety like a light switch. It's effect lasted long enough that I thought it permanent. My anxiety and doubts and lack of self worth was gone. Anything that can make you love yourself should be legal.
  • Psilocybin saved my life . I was addicted to heroin for 15 years and after Psilocybin treatment I will be 3 years clean in September . I have zero cravings . This is something that truly needs to be more broadly used in addiction treatment .
  • @royperry1165
    Psychedelic really healed me years back. These are great healing compounds! When used in proper context.
  • @RobPendy
    I just tried DMT and MUSHROOMS for the first time. I felt as if i was in the center of the universe. I didn't go crazy after such an extreme experience. Totally got rid of depression, anxiety and illicit pill addiction.
  • Psychedelics are just an exceptional mental health breakthrough. It's quite fascinating how effective they are against depression and anxiety. Saved my life.
  • @S1X_Bucks
    I had the universal empathy experience once. I felt the world's suffering, and it's changed me forever. Love you guys.
  • @TheGoIsWin21
    As someone with both Chronic Depression and PTSD, I have experimented with Psilocybin. While I didn't experience the "life changing" trip as some people describe, it's absolutely impossible for me to say that it did not vastly improve my mood and my internal dialogues in ways that were profoundly helpful.
  • Psychedelics have the potential to make a significant impact on mental health issues like anxiety and depression. They've been incredibly helpful for me personally.
  • Psilocybin has saved my life. I was suicidal all my life. I researched this topic heavily. I microdosed, .25 of a gram. I do daily, four times a day. I do not hallucinate. It helps bring mental clarity, helps me to think outside the box. It helps me to see that life is beautiful, amazing. I am no longer suicidal. ❤
  • @jenmdawg
    I was grief stricken a year ago. Unable to function after my fiancé died traumatically I could only find relief in plotting how to make my death not look like suicide. I took a micro dose of mushrooms he’d left behind and went to bed expecting nothing to happen. 90 minutes later I was in my kitchen doing the dishes. Then I walked the dog and felt sun on my face. Then I ate dinner for the first time in weeks, drank water and went to bed. My grief was still there - painful, raw and vivid but somehow I understood that I would make it and that life was going to show me the way and let joy in again. Edit; I didn’t want my death to look like suicide - I wanted to find a way to have an “accident” that didn’t put anyone else at risk.
  • @KJ99otis
    Other than growing a human in my body and birthing her, my first mushroom trip at age 63 was the #1 PEAK experience of my life. It changed everything for me. Truly magnificent and magical. I now do a medicinal heroic dose every 4 or 5 weeks. I wish I would have been open to this sacred medicine decades ago. I know I would have eliminated 40+ years of severe depression and lived a richer life. So I begin to invent myself now, into the person I most want to be in the last chapters of my life. With the help of these beautiful transformative plant teachers. So grateful!
  • Had a heroic dose 8 years ago, still talking about it with enthusiasm! My experience was profound. After that, it became a sacrament and not a thing to treat lightly. I have so much respect for psilocybin. A divine respect. Changed my life. ❤
  • Psychedelics such as psilocybin mushrooms, have demonstrated great potential in supporting individuals dealing with mental health challenges.
  • After my experience. Woke up one day and have not drank alcohol since. Definitely life changing.
  • My first trip was close to 38 years ago on LSD (I'm 60 now). It was done with some friends who were experienced in it. I remember being about 30 minutes into having taken it and being asked if I felt anything. I remember starting to say that I felt nothing out of the ordinary when all of a sudden this deep within my soul laughter just came bursting out. Game on. I really do remember that night as if it were yesterday. I also remember having looked into a mirror that night and I swear that I saw my soul opened up to me in its entirety to a point that I new I could never lie to myself. It also made me for years to come, find friends from the teenage years gone by that I had lied to or done wrong to and apologize and ask forgiveness. It's now been close to 30 years since my last trip, but its lessons from that first time still guide me to this day.
  • @Cris.Arce-ru4eq
    I had a psychedelic experience once that sent me to eternity and meeting the creator. My ego dissolved yet I was physically terrified. It's effect lasted long enough that I thought it permanent. It was so magical and so full of love, changed my life for good. In the most positive way possible.
  • @hermenutic
    I last took LSD in 1971 and I regard it to this day as one of the most ground breaking formative experiences I've had. I came away feeling as if I had witnessed the primal scene of the universe and that it was something humans weren't supposed to be privy to. I'm glad I had the experience.