CHARCOT MARIE TOOTH DISEASE (CMT)

Medical Centric
Medical Centric
41,897
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Published 2022-12-08
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Chapters

0:00 Introduction
1:01 Causes of Charcot Marie tooth disease (CMT)
4:07 Diagnosis and treatment of Charcot Marie tooth disease (CMT)
4:51 Treatment for Charcot Marie tooth disease (CMT)


Charcot–Marie–Tooth disease (CMT) is a hereditary motor and sensory neuropathy of the peripheral nervous system characterized by progressive loss of muscle tissue and touch sensation across various parts of the body. This disease is the most commonly inherited neurological disorder, affecting about one in 2,500 people.[3][4] It is named after those who classically described it: the Frenchman Jean-Martin Charcot (1825–1893), his pupil Pierre Marie (1853–1940),[5] and the Briton Howard Henry Tooth (1856–1925).[6]

There is no known cure. Care focuses on maintaining function. CMT was previously classified as a subtype of muscular dystrophy.[3] Symptoms of CMT usually begin in early childhood or early adulthood but can begin later. Some people do not experience symptoms until their early 30s or 40s. Usually, the initial symptom is foot drop early in the course of the disease. This can also cause hammertoe, where the toes are always curled. Wasting of muscle tissue of the lower parts of the legs may give rise to a "stork leg" or "inverted champagne bottle" appearance. Weakness in the hands and forearms occurs in many people as the disease progresses.[7]

Loss of touch sensation in the feet, ankles, and legs as well as in the hands, wrists, and arms occurs with various types of the disease. Early- and late-onset forms occur with 'on and off' painful spasmodic muscular contractions that can be disabling when the disease activates. High-arched feet (pes cavus) or flat-arched feet (pes planus) are classically associated with the disorder.[8] Sensory and proprioceptive nerves in the hands and feet are often damaged, while unmyelinated pain nerves are left intact. Overuse of an affected hand or limb can activate symptoms including numbness, spasm, and painful cramping.[7]

Symptoms and progression of the disease can vary. Involuntary grinding of teeth and squinting are prevalent and often go unnoticed by the person affected. Breathing can be affected in some, as can hearing, vision, and neck and shoulder muscles. Scoliosis is common, causing hunching and loss of height. Hip sockets can be malformed. Gastrointestinal problems can be part of CMT,[9][10] as can difficulty chewing, swallowing, and speaking (due to atrophy of vocal cords).[11] A tremor can develop as muscles waste. Pregnancy has been known to exacerbate CMT, as well as severe emotional stress. Patients with CMT must avoid periods of prolonged immobility such as when recovering from a secondary injury, as prolonged periods of limited mobility can drastically accelerate symptoms of CMT.[12]
All Comments (21)
  • @sobble821
    I have this (I'm 14 years old) but I just got approved for a big surgery to help extend my tendons next month so yay!
  • @terrie001
    It hurts and I am so dishearten when I see my little nephew living with this each day as he grows. The poor boy still think he is normal right now and didn’t question his difference. I can’t imagine when he starts to realize he is not the same as others in school, and worse when other kids start to question him about his walking posture. Just today, I had to help clean his fingers with my hands through the running water. His fingers were all curled up, and he doesn’t know to use his own fingers to rub off the dirty stuff. I was tearing inside, and now in the middle of the night, I am watching this, tearing in my bed. Imagining what is ahead of his life and what his future may entails. 😢
  • @thiccbaby2967
    I was born with cmt. From my dad side. He has it and three of my sister’s also do. Its mainly my feet and legs. My feet turn inward so it looks funny to people when i walk and especially run. Im 27 now. No surgeries since my parents always denied any type of surgery for me as a child. If i do day any thing where I’ve stayed on my feet for only minutes, let alone hours at like work. When i was younger. I didn’t feel much pain. All through middle school i walked home and to school and as to other friends houses. Wasn’t till sometime after highs school. Where every night i would feel pins sticking me on the pressure points where i bare my entire weight. Which is a small ball on the side of my foot. Which is out it bends and causes me to fall over simple pebble, sidewalk crack, and acorns. Constant foot rolls and randomly tripping on nothing would always happen. Especially walking to and from school. Where the neighbor i live in has shit sidewalks. And when it would just to uneven grass or just straight dirt. Those where my biggest enemies. Where only flat and solid was where i stood a chance of not embarrassing myself.
  • @youngboy3814
    Wish thier way a cure my life is a living hell and I’m only 18 ..been going thru severe nerve pain for about a 2 years now.. it’s sad that thier no cure . No medication has helped me .. I’ve tried duluxatine ,gabapentin and I take 4 ibuprofens a day and I get no sighn of relief… idk what to do my life is miserable I can’t even work . I can’t even take my pups on a walk… plz pray they find a cure …
  • @yoxn.jexnghxn
    I’m 14 and I have this it started at around the age of 3 it’s a living hell when I fall I can’t stand back up when I lie down I feel uncomfortable with my legs I can’t hold balance or run I can’t jump or play sports my dream was to be a soccer player.. at 7 years old I also dreamed of being a doctor and treating myself since no one could find a treatment for me..
  • @gaelleletourneau5391
    i have this deseas and its really sad alwais being less performant in phisical education class at school becaus they do not know why and also my foot looking diferent makes me cry every time i think about it and only 2 of my friends know what i have and knowing that it will only get worst is so depressing
  • @gbosearcher-3686
    My sister in law has this disease. A terrible disease. Took years to figure out what exactly was wrong with her.
  • @Suaviso
    I’m 31 going on 32 with this issue and honestly CMT has ruined my life
  • @limixl
    I wasn't born with but i jumped from a trampoline when i was 2 and now i have it
  • @kevinfitzgerald7474
    Yeah I've been told to watch out for scrapes and cuts in my lower legs so they don't get worse. But I was never told that lyme disease, tick diseases, environmental illnesses can also worsen cmt symptom. Cmt is not a disease, it's a symptom of a hereditary long haul environmental illness that cause demyelinating peripheral nueropothy. This medical system is solely just ocd in symptoms. It's not a disease. Well I have a tick disease, mold of long haul, just like the one that caused cmt which has worsened my cmt and these Environmental illnesses do worsen cmt symptom. The numbness that I had in my lower legs is going away by using supplements, nutritional ivs and detoxing. Stem cells can reverse, repair these nuerological problems.
  • @l.b.603
    Geez. I am 65 and have all the symptoms they talk about here on this video. I have stayed away from doctors, practice yoga every day and live my life. I haven't gone to physical therapy or occupational therapy. When I need to find a way to do something, I do it. If you focus on something, you become it. If you see yourself as poor me I have this disease, then you're not going to be happy. You are not a victim! Stop focusing on your disease and live your lives. Just get on with it. Yay I fall sometimes; Yay I can't run. Yoga helps Immensely with balance, gait, movement and so forth. Staying thin helps. I am plant based. Fat leads to joint problems and more muscle loss. Get thin and remain thin. Be thankful for what you have folks!