Oxygen Is Killing You | Answers With Joe

"why do we stare in the fire?" My dad always called fire "caveman television" on camping trips. Funny to hear that there is some truth to that statement.

One of the first 'Philosoraptor' memes was: "What if oxygen is actually toxic and just takes 80-100 years to kill you?" Philosoraptor is wise.

Pro tip: By staying underwater for an extended period of time, the atmosphere can't kill you anymore. I mean, the lack of it will, much faster, but the atmosphere won't kill you.

Admittedly i already know what joe is talking about before even watching the video on this one. doesn't matter though, I want to know what Joe has come to learn and witness his dread and sense of impending doom play out, priceless. Love you buddy.

goddammit Joe you're right - oxygen is killing me - going to give up that nasty oxygen addiction right now...

nothing makes you feel dumber than when joe says "now you've probably heard of this before" and you haven't heard of it before...

“We are in a way, living flame. But the fire fades” - Joe, a man who secretly plays DarkSouls

Ever seen the meme about "Planet of the 'slow burning'"? It was one of those existential joke memes to explain why aliens might avoid Earth because we are all slowly burning and breathing poison like some kind of freaky demons lol

4:00 - Supernova is needed only to disperse oxygen - unlike elements heavier that iron, it is mainly produced by good old fusion inside stars, specifically in CNO cycle.

I just realized why this channel is so successful. Joe talks as if what he's talking about is common knowledge, making us feel familiar with the subject. Cyanobacteria, I know right!🤗

I'm an arborist... So I've burned unknown amounts of brush in my life. Even then im never not completely mesmerized by it. It's truly so enigmatic and provoking yet calming and comforting.

People bad at chemistry: "Oxygen is flammable" Me: Slap "NO IT'S NOT"

Joe you claimed all elements heavier than Hydrogen and Helium are created in supernova, that's not true. Stars can form up to Iron through fusion, anything heavier than that requires supernova.

Oxygen is one of the most electronegative and reactive elements out there. Its like evolving to thrive in fluorine or something. Kinda crazy when you think about it like that.

So poetic and then starts talking about “bacteria farts”

“It’s probably a big mistake.” Did Joe just reference Douglas Adams? Love me some Hitchiker’s Guide.

Human aging is a heck of a lot more complicated. In fact, they have found that higher pressure oxygen in a hyperbaric chamber can extend telomeres in the blood, likely extending life. Quantum tunneling as a result of the heat producing bonds that otherwise are not energy favorable is a major source of aging (by probability, several photons of heat energy concentrate in a localized area providing the energy for the damaging reaction which is more common at higher body temperature). This is why most of the organisms that outlive us are colder than we are. We can't just choose to be cold, and live longer, though. We have enzymes that are required for even the most basic cellular operations, such as the reactions in mitochondria that produce ATP. Those other organisms have different enzymes. So they can endure internal temperatures that would kill us. And while this is a major form of aging, it is just one of several. We accumulate a protein called Glucosepane. It is a lysine-arginine protein cross-linking product and advanced glycation end product (AGE) derived from D-glucose. This makes a mess of collagen in our bodies over time. The other AGEs, as long as we produce and ingest relatively small amounts (by avoiding things cooked at high temperature, whipped, churned, ground or otherwise processed at high speed by machine, or fermented, and by having ample vitamins) can be processed by the liver (as long as the liver stays healthy) and expelled by the body. This Glucosepane crap could probably kill you just by itself, by stiffening tissue, so much that it no longer functions. Then there are toxins that accumulate in your blood. That can be removed by plasmaphereses. But who does that just to clean their blood? Then there are changes to molecules that connect to our DNA. This methylation aging we have no way to reverse without killing you...yet. And if we could turn back that clock, how would we do it uniformly? What happens when you have cells that all think they are different ages? The ends of chromosomes shorten with every cellular division. When the chromosome ends (telomeres) reach the end, the cells can no longer divide, but more than that, they can become nasty. They can start to gorge themselves eating other cells, and spewing chemicals that kills and harms other cells. These senescent cells also accumulate as more and more cells run into their division limit (Hayflick limit). There are things we can do to reduce the number of these things like periodic fasting or near fasting, and taking senolytics like quercetin and fisetin periodically, but it is almost certainly a loosing battle. Mitochondria can also go bad making a mess and killing cells accelerating divisions to replace those damaged cells, which makes more cells run into that division limit. Though, it is possible to refresh your mitochondria by doing very unpleasant HIIT (high intensity interval training) exercise very regularly. And while hyperbaric oxygen and a few molecules we have found can extend telomeres...that is probably limited to the immune system and the blood. Anything further reaching, probably would require genetic modification.

Your hosting skills were always good, but it's been so fun to watch them evolve to where they are now. Your scripts are fluid, your jokes land most of the time, your hosting personality is developing beautifully, and you're really hitting your stride.

You can heal 5 times more quickly in a hyperbaric chamber at 100% oxygen and 3x atmospheric pressure.

Holy crap haha I was second camera on Nigel Blows Stuff up. Happy to see it having a second life on Curiosity