Stem cell ageing and rejuvenation | Prof Heinrich Jasper

NUS Medicine
NUS Medicine
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Publicado 2022-04-21
In this #webinar, Professor Heinrich Jasper, Principal Fellow and Director of Genentech Inc. and Professor at the Buck Institute for Research on Ageing in California, USA, explains how stem cell #decline can contribute to the loss of regenerative capacity and how we can leverage epigenetic reprogramming to rejuvenate #ageing tissues.

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References:
- Closing video source:    • 'What A Ride' 90-Year Old Ironman Lew...  

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Todos los comentarios (9)
  • @peterz53
    Thank you for this presentation. Interesting connection with 2021 work out of Sonnenburg Lab in which fermented foods were shown to reduce a range of inflammatory markers. Seems a diet which helps maintain human gut barrier function would be desirable for many reasons (CD38/NAD+, inflammation control, NAD+/NAMPT/OSKM).
  • @immortalityIMT
    So according to your theory, the micro-environment is altered which increases the risk of cancer, the immune system then is altered in response and targets stem cells as a potential source of that cancer because of their replication and the regeneration becomes heavily restricted and aging proceeds?
  • @NorCalFellow0172
    Would you be able to add links to some of the papers that Prof. Jasper mentions? In particular, links would be appreciated to the partial reprogramming protocol articles he used in the mouse studies he describes at the end of his presentation.
  • @immortalityIMT
    I wonder which molecule increases lifespan or heathspan the most. Any ideas? Why don't Planaria get teratoma?
  • @divinediscoverys4551
    Very interesting. I believe you haven't tried the most powerful technology out there that regenerates new stem cells. Your study isn't as powerful as this. Anyone reading this, reach out to me so I can share with you what it is.
  • @gerryscally3547
    We have been looking at agelessrx. Metformin suggesting that oligodendrocyte precursor cells are regenerated by Metformin allowing myelin regeneration by oligodendrocytes Is Metformin working Gerard Scally